p90 RSK (Phospho-Thr573) Antibody

Dodavatel:	Reddot Biotech USA Inc.
Teplota skladování:	Store at -20°C. Avoid freeze / thaw cycles.
Katalogové číslo:	RDSA62379
Velikost balení:	100μL
Cena bez DPH:	9 274,00 Kč
Dostupnost:	NA OBJEDNÁNÍ

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This is a p90 RSK (Phospho-Thr573) Phospho-Specific Antibody from Reddot Biotech. This product is for Research Use Only.

Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes.

Technická specifikace

Clonality		Polyclonal
Purification Method		Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatography using non-phosphopeptide.
Isotype		IgG
Host		Rabbit
Immunogen		Peptide sequence around phosphorylation site of threonine 573(L-M-T(p)-P-C) derived from Human p90 RSK.
Gene ID		6195
Swissprot		Q15418
Observed MW		95kDa
Reactivity		Human
Applications		WB,IHC
Conjugation		Unconjugated
Dilution		WB 1:500-1:1000, IHC 1:50-1:100
Concentration		1.0 mg/mL
Buffer		Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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p90 RSK (Phospho-Thr573) Antibody

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