Cleaved-CASP3 p17 (D175) Polyclonal Antibody
| Dodavatel: | Reddot Biotech USA Inc. | |||||||||||||||||||
| Teplota skladování: | Store at -20°C. Avoid freeze / thaw cycles. | |||||||||||||||||||
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This is a Cleaved-CASP3 p17 (D175) Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.
| Clonality | Polyclonal | |
| Purification Method | Affinity purification | |
| Isotype | IgG | |
| Host | Rabbit | |
| Immunogen | Synthesized peptide derived from the Internal region of human Caspase-3 p17 | |
| Swissprot | P42574 | |
| Calculated MW | 32 kDa | |
| Observed MW | 20 kDa | |
| Reactivity | Human,Mouse,Rat | |
| Applications | WB,IHC-p,IF,ELISA | |
| Conjugation | Unconjugated | |
| Dilution | WB 1:500-2000, IHC 1:50-300, IF 1:50-300 | |
| Concentration | 1 mg/mL | |
| Buffer | PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4 |
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