EGFR (Phospho-Tyr1086) Rabbit mAb

The epidermal growth factor (EGF) receptor is a transmembrane tyrosine kinase that belongs to the HER/ErbB protein family. Ligand binding results in receptor dimerization, autophosphorylation, activation of downstream signaling, internalization, and lysosomal degradation. Phospho-EGF Receptor (Tyr1086) Antibody is directed against a previously unpublished EGF receptor phosphorylation site at Tyr1086, Phosphorlation of EGF receptor at Tyr1086 was observed in select carcinoma cell lines and in tumors.