This is a Notch1 Rabbit mAb Recombinant Antibody from Reddot Biotech. This product is for Research Use Only.
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis;negatively regulates endothelial cell proliferation and migration and angiogenic sprouting.